Here is a quote attributed to President Calvin Coolidge …
“Nothing in this world can take the place of persistence. Talent will not; nothing is more common than unsuccessful people with talent. Genius will not; unrewarded genius is almost a proverb. Education will not; the world is full of educated derelicts. Persistence and determination alone are omnipotent. The slogan ‘press on’ has solved and will always solve the problem of the human race.”
The point Coolidge makes is when faced with challenges, setbacks and failures, persistence wins. Innovations don’t just happen overnight and often require persistence in testing and development. Scientists and inventors understand this and move forward through each iteration of testing driven by the belief that they must prove out (or disprove) the idea.
As an entrepreneur, it comes down to having a strong conviction about your vision, creating a plan and working that plan to fruition. New discoveries, products and innovations are not won in a lottery pool and rarely possible to make a quick buck as an entrepreneur.